What does Constance Therapeutics do?

Constance Therapeutics is a vertically integrated medicinal cannabis company that is setting the industry standard for quality, potency and consistency with a new category of whole plant cannabis extracts.

The company is helping usher in a new era of care, in which whole plant cannabis extracts are integrated into traditional healthcare to provide physicians and their patients with expanded treatment options, filling the gap between traditional pharmaceuticals and commonplace cannabis products.

Constance Therapeutics’ whole plant cannabis extracts are based on scientific research, specifically “The Entourage Effect” theory, which shows that whole plant cannabis extracts from the female cannabis plant are more effective than isolated compounds. Constance Therapeutics’ tightly controlled, quantitatively-defined and patent-pending extraction method is based on scientific and engineering principles. The company works alongside physicians and medical professionals to provide integrative health options to cancer patients and those suffering from other debilitating diseases.

 

Why do you call CT "the standard-bearer for medicinal cannabis"?

We have led the charge in setting the highest standards in the medicinal cannabis industry. Constance Therapeutics offers standardized products, specific protocols and individualized patient member services. Our scientific methods are in stark contrast to the previous era of “medical marijuana,” in which smoking the cannabis plant, using crude extracts and producing products with varying degrees of consistency left few, if any, viable options for efficacy, dosage, ongoing management and monitoring.

Constance Therapeutics has created a new category of whole plant cannabis extracts that provides additional treatment options and fills the gap between traditional pharmaceuticals and commonplace cannabis products. They are the first to deliver medicinal cannabis extracts that provide additional treatment options to physicians and their patients for conditions where previously only pharmaceuticals may have been prescribed.

 

When was Constance Therapeutics founded?

Constance Finley has been actively producing whole plant cannabis extracts, in compliance with California law, since 2008.

 

How did you get involved in the industry?

Constance Finley, founder and CEO of Constance Therapeutics, was inspired by her own personal experience with ankylosing spondylitis, a rheumatology condition similar to rheumatoid arthritis. Difficulty in diagnosing this led to the loss of her career as an investment banker and entrepreneur, and to her being housebound for 15 years. Once properly diagnosed, Finley nearly died from the pharmaceuticals prescribed to help alleviate pain and inflammation caused by the condition, and she turned to medicinal cannabis for relief.

She quickly became fascinated with the science behind the medicinal benefits of cannabis and immersed herself in all the information and research available. Studies have found that cannabinoids, like THC and CBD, are more effective when working in tandem with the entire phytochemical profile of the female cannabis flower versus working in isolation – what is known as “The Entourage Effect.”

Based on her research, Finley became determined to make standardized, whole plant cannabis extracts that incorporate all the naturally occurring cannabinoids, terpenes and flavonoids in cannabis, and that are safe for those with compromised immune systems. Constance Therapeutics is now ushering in a new era of patient care and superior standards in order to provide physicians and their patients with expanded treatment options where previously only pharmaceutical medications were prescribed.

 

Who uses Constance Therapeutics’ products?

Constance Therapeutics works in conjunction with physicians and medical professionals to provide integrative medicine options to physicians and their patients suffering from serious conditions, often in cases where previously only pharmaceuticals may have been prescribed.

We have been told that our products have been used as an integrative treatment option for cancer, Lyme disease, chronic pain, autoimmune diseases, nervous system diseases and more.

 

How is Constance Therapeutics different from other cannabis therapeutics suppliers?

Constance Therapeutics is the first to achieve this level of potency (3x what had previously been the industry standard) and purity in the medicinal cannabis hotbed that is Northern California. The company’s products are:

  • Based on modern herbalist principles of synergy between plant compounds and scientific research, specifically the “Entourage Effect,” which shows that whole plant cannabis extracts from the female cannabis plant (not hemp) are more effective than isolated compounds, such as CBD only.
  • Produced from fully trimmed, female, unfertilized cannabis sativa flowers of plants with known genetics that have been sustainably grown by in-house or collaborative farms that have entered a formal relationship with Constance Therapeutics and ascribe to the terroir philosophy.
  • Extracted with certified-organic, pharmaceutical-grade ethanol through a tightly controlled, quantitatively defined and patent-pending process that is based on scientific and engineering principles.
  • Third-party tested, and routinely cross-tested at the industry’s most respected laboratories.
  • Utilized by physicians and medical professionals as an integrative treatment option for those suffering from serious conditions.
 

What do you mean by “whole plant cannabis extracts?"

Whole plant cannabis extracts are developed from fully trimmed, female, unfertilized cannabis sativa flowers of plants. They incorporate all of the naturally occurring cannabinoids – including CBD, THC, terpenes and flavonoids – found in the female cannabis flower. Constance Therapeutics’ extracts are based on modern clinical herbalist principles of synergy between plant compounds and scientific research, specifically “The Entourage Effect” theory, which shows that whole plant cannabis extracts from the female cannabis plant (not hemp) are more effective than isolated compounds, such as CBD only.

Several studies, including one by Dr. Ethan Russo, one by Dr. Jahan Marcu, one by Wai Liu (senior research fellow at St George’s, University of London) and one by Aberdeen University have shown that the many cannabinoids found within the cannabis plant are more effective, and are particularly adept at killing cancer cells in academic research modalities, when they work together. As science has shown us that eating real fruits, vegetables and other plants provides better nutrition than just taking vitamin pills with one nutrient or mineral in each, science is now showing us that we can likely say the same about cannabis.

 

Other cannabis extracts have lower amounts of THC than those produced by Constance Therapeutics. Why does Constance Therapeutics use such a high amount of THC?

Constance Therapeutics puts a particular emphasis on THC because academic research indicates that it is an essential phyto-cannabinoid for serious conditions. Recently, there has been a shift in focus to CBD and its various therapeutic properties, but THC is also necessary in order for cannabis to be the most beneficial and effective; there is a synergistic effect when all the naturally occurring cannabinoids are included within the extracts. “The Entourage Effect” theory shows that whole plant cannabis extracts from the female cannabis plant are more effective than isolated compounds, such as CBD only. The reality is that both are important and both are necessary to realize this plant’s full potential.

 

What makes your extracts different from others?

Constance Therapeutics’ primary differentiators are:

  • Constance Therapeutics is the only one in our unique category that can guarantee standardized products with the highest quality, potency and consistency.
  • Constance Therapeutics’ whole plant cannabis extracts are based on modern herbalist principles of synergy between plant compounds and scientific research, specifically the  “Entourage Effect,” which shows that whole plant cannabis extracts from the female cannabis plant (not hemp) are more effective than isolated compounds, such as CBD only.
  • Constance Therapeutics’ tightly controlled, quantitatively defined and patent-pending extraction method is based on scientific and engineering principles.
  • Each lot of extracts is third party tested and routinely cross-tested at the industry’s most respected laboratories, including Excelsior Analytics and Sonoma Labs.
  • Constance Therapeutics whole plant cannabis extracts are obtained from only raw materials with known and controlled genetics that have been sustainably grown by farmers who ascribe to the terroir philosophy.
  • The company continuously verifies that all collaborative farmers maintain the approved growing methodology and soil quality as mandated by Constance Therapeutics via extensive third-party testing and unannounced site visits.
 

How are your extracts produced?

Constance Therapeutics’ tightly controlled, quantitatively defined and patent-pending extraction method is based on scientific and engineering principles using only pharmaceutical grade, certified-organic ethanol. According to the research from the International Association of Cannabinoid Medicines, as an extraction solvent, ethanol has been shown to perform the best at extracting the full range of terpenes and cannabinoids present in cannabis plant material. Additionally, ethanol is safe for consumption. Finally, each lot is third-party tested and routinely cross-tested at the industry’s most respected laboratories, including Excelsior Analytics and Sonoma Labs.

 

Can someone outside of California obtain your extracts?

Constance Therapeutics does work with patients that reside in other states and countries. Due to legal restrictions, all patient members must possess a physician recommendation and a California cannabis card in order to purchase products; this includes out-of-state patient members. Out-of-state patient members must remain within California while they are in possession of Constance Therapeutics products and must not cross state lines.

It is heartbreaking to receive inquiries from people we are not able to help due to the current legislation. Constance Therapeutics hopes that one day the laws will adapt so that those in need of medicinal cannabis will be able to obtain it, regardless of where they live.